Colorectal cancer updates


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Ki is a marker of cell proliferation associated with a low survival in colorectal cancer patients. Its expression is increased in patients with Dukes C or D colorectal cancer versus those in stage A or B.

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The purpose of the study is to evaluate the immunohistochemical expression of the Ki marker in colorectal adenocarcinomas. The study was performed on a group of 28 patients diagnosed with rectal cancer.

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We made the histopathological and immunohistochemical evaluation of patients in the study group. The evaluation was performed on the sections stained with hematoxylin-eosin, and for mucinous forms, on sections stained with alcian blue.

The topography of the Ki reaction is strictly nuclear, evident in areas with intense proliferative activity. In cases with a strong positive response to Ki, the prognosis is worse, with invasion of the perirectal tissues and colorectal cancer updates.

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  • Its expression is increased in patients with Dukes C or D colorectal cancer versus those in stage A or B.

The lack of Ki expression in nearby neoplastic tissues suggests that cancerous tissue proliferates in a pathway that it is not correlated with adjacent tissues. The Ki could be useful in the prognosis of patients with colorectal cancer.

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Keywords: colorectal cancer; Ki immunohistochemical expression; colorectal cancer updates Issue:Volume 70, Issue 1 Pages: