While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases metastatic cancer liver improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease.
To improve these dismal metastatic cancer liver, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential. Once cancer cells enter the liver, several different scenarios may occur.
The metastatic cancer liver cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact metastatic cancer liver cancer liver early stages of the metastatic process.
The unique microenvironment of the metastatic cancer liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted.
In addition, the role of inflammation pre-existing and tumor-inducedhost innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge.
Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management metastatic cancer liver hepatic metastases.
These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics metastatic cancer liver as anti-angiogenic drugs as treatment modalities. Cellular and molecular aspects of the liver architecture and function. The tumor microenvironment at different stage of hepatic metastasis.
Role of CXC chemokines and receptors in liver metastasis — impact on liver resection-induced engraftment and tumor growth.
Role of Inflammation in the early stages of liver metastasis.
Signal transduction in tumor-endothelial cell communication. Tumor dormancy in liver metastasis: clinical and experimental evidence and implications for treatment. Role of the IGF- axis in liver metastasis: experimental and clinical evidence.
Breast Cancer Liver Metastasis. Imaging of Hepatic Metastases. Proteomic profiling of hepatic metastases: Paving the way to individualized therapy.
Targeting Angiogenesis in the Treatment of Hepatic Metastasis. Uveal melanoma — a paradigm of site-specific liver metastasis.
- Citate duplicat Abstract Aim: Malignant tumors localized in the digestive tract have a tendency to local growth and invasion with lymph node colorectal cancer liver metastasis.
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