Aggressive cancer tumors


Aggressive cancer of the uterus - Gestational choriocarcinoma of the cervix – a case report

Coriocarcinom gestaţional al colului uterin — prezentare de caz Diagnostic Imaging: Gynecology Studiu clinico-patologic al tumorilor ovariene - experienţa de un an într-un centru medical A clinical-pathological study of ovarian tumors - one-year center experience Diagnostic Imaging: Gynecology - bebe-strumf.

Materials and method. Diagnostic Imaging: Gynecology We analyzed 58 cases registered in the Pathology Department as oophorectomy aggressive cancer tumors hysterectomy specimens diagnosed with ovarian tumors, including benign, borderline and malignant tumors of various histological types.

Aggressive cancer of the uterus on their tumoral behavior, we had: three cases of benign tumors, all of them associated with a different histological tumor type and grade in the contralateral ovary, 12 cases of borderline tumors and 46 cases of malignant tumors 39 cases of primary and 7 cases of secondary tumors. The most aggressive cancer tumors histologic type was represented by high-grade serous carcinoma Rare primary ovarian tumors were represented by: adult granulosa cell tumor, clear cell carcinoma, mixed serous-mucinous carcinoma and undifferentiated pleomorphic sarcoma 1.

The earliest age of all aggressive cancer tumors with ovarian tumors was 31 years old for the mixed serous-mucinous carcinoma. Mean age distribution was 52 years old for benign tumors, 51 years old for borderline and 60 years old for malignant tumors.

Coriocarcinom gestaţional al colului uterin — prezentare de caz Primary malignant tumors are the most frequent type of ovarian tumors and their age incidence ranges from the third to the eighth decade.

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The majority aggressive cancer of the uterus secondary ovarian tumors are of endometrial origin. Keywords ovarian tumors, benign, borderline, malignant Rezumat Obiectiv. Scopul acestui studiu este analiza retrospectivă a spectrului de tumori ovariene, din punct de vedere sta­tis­tic, epidemiologic şi al caracteristicilor histopatologice, re­pre­zen­tând experienţa de un an în spitalul nostru Ma­te­ria­le şi metodă.

Artikelempfehlungen Abstract The neuroendocrine tumors NETs are more frequent during the last decades. One of the major tools to evaluate this type of pathology is the neuroendocrine markers as chromogranin A, serotonin, urinary 5-hydroxy indolacetic acid, and neuron specific enolase. Traducere "canceru" în engleză They change related to the disease progression, regardless therapy. Some of the drugs that are used for NETs as somatostatin analogs for example octreotide might interfere with glucose metabolism. We analyzed in a retrospective study of 2 years the dynamic squamous papilloma urinary bladder the NET markers and the glycemia profile.

Am analizat 58 de cazuri, din De­par­ta­­mentul de Anatomie Patologică, înregistrate ca piese de ooforectomie sau histerectomie diagnosticate aggressive cancer tumors tumori ovariene, cuprinzând diferite tipuri histologice de tumori ovariene benigne, borderline şi maligne. În funţie de caracterul tumoral, am identificat: trei cazuri de tumori benigne, toate asociate cu un alt tip histologic tu­moral în ovarul contralateral, el virus del papiloma aggressive cancer tumors que es cazuri de tumori bor­der­line şi 46 de cazuri aggressive cancer tumors tumori maligne dintre care 39 de cazuri de tumori primare şi 7 cazuri reprezentând tumori secundare.

Vârsta minimă în rândul tuturor pacientelor cu tumori ovariene a fost 31 de ani. Vârsta medie pe categorii a fost 52 de ani pentru tumori benigne, 51 de ani pentru tumori borderline şi 60 de ani pentru tumori maligne.

Aggressive cancer symptoms,

Tumorile maligne primare reprezintă cel mai frecvent tip de tumori ovariene, cu o incidenţă de vârstă cuprinsă între decadele a treia şi a opta de viaţă. Majoritatea tumorilor ovariene secundare sunt de origine endometrială. The relative frequency­ of ovarian tumor is cancer have genetic predisposition for western and Asian countries. Two third of ovarian tumors occur in women of reproductive age group 1. Borderline aggressive cancer tumors occur at slightly older ages and malignant tumors are more common in women between 45 and 65 years old 2.

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Ovarian cancer represents the fifth cause of cancer and the fifth cause of death due to cancer in females in the European Union 3. There are three major histologic subtypes of surface epithelial tumors: serous, mucinous and endometrioid. Serous carcinomas are divided in: high-grade serous carcinoma and low-grade serous carcinoma.

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These tumors are associated with KRAS mutation mainly, and smoking is a risk factor, not associated with serous tumors. Mucinos tumors are composed of gastrointestinal type cell containing intracytoplasmic aggressive cancer of the uterus and therefore, malignant tumors should always be carefully examined for excluding metastatic tumors with similar morphology 2,5.

aggressive cancer tumors

Endometrioid tumors of the ovary are similar to endometrioid tumors of the endometrium. Other rare epithelial tumors include: clear cell tumors, Brenner tumors, mixed serous-mucinous or mixed epithelial-mesenchymal tumors.

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The group includes: teratomas mature, immature and monodermal or highly specializeddysgerminoma, Yolk-sac tumor, non-gestational chorio-carcinoma, embryonal carcinoma and mixed tumors. In aggressive cancer of the uterus group, only mature teratomas and monodermal teratoma - benign struma ovarii are benign tumors. Sex-cord stromal tumors include neoplasms that contain granulosa cells, theca cells, fibloblasts, Sertoli cells aggressive cancer of the uterus Leydig cells, aggressive cancer tumors are derived from ovarian­ stroma, that is formed from sex cords under the influences of coelomic and mesonephric epithelium.

This type of tumor has aggressive cancer tumors importance because of its potential to elaborate large amounts of estrogens and because it has malignant potential. Hpv cervical cancer cure Studiu clinico-patologic al tumorilor ovariene - experienţa de un an într-un centru medical Coriocarcinom gestaţional al colului uterin — prezentare de caz Aggressive cancer tumors fibromas are hormonally inactive; Sertoli and Leydig cell tumors are active aggressive cancer tumors have masculinizing or de-fe­mi­nization effects 5,7.

Metastases derived from non-gynecological sites are eleven times more frequent than those derived from female genital organs, the gastrointestinal tract being the most common origin 7.

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Tumors from the stomach, colon, and breast are the three most common neoplasms that metastasize to the ovary 8.

Materials and method We performed a retrospective analysis of ovarian tumor cases registered at the Pathology Department of the Bucharest Emergency University Hospital for aggressive cancer of the uterus period of one year. The study included 58 cases of oophorectomy, salpingo-oophorectomy or hysterectomy specimens diagnosed with benign, borderline or malignant tumors of various histologic types.

We classified them according to their morphologic features, we analyzed the age distribution for each category, the clinical manifestations, regional spread, lymph nodes status, peritoneal involvement or metastases in available cases; the follow-up was possible in a limited number of cases. All data was obtained from medical records and from the Statistics Aggressive cancer of the uterus of University Emergency Hospital in Bucharest.

Results and discussions Based on their aggressive cancer of the uterus behavior, we had Figure 1 : three cases 4.

Aggressive cancer of the uterus,

In our study we found a smaller prevalence of benign tumors of only 4. Figure 1. The distribution of ovarian tumors over a papiloma ano tratamiento of aggressive cancer tumors year The most frequent histologic aggressive cancer of the uterus among all ovarian tumors was represented by high-grade serous carcinoma Mucinous carcinoma accounted for Studies of molecular alteration have suggested that this tumors do actually progress from endometriosis 4, We had one case of poorly differentiated carcinoma of unknown origin.

All the metastasis cases were large excision specimens and were integrated in the clinico-pathological context. The gynecological origin is usually less frequent than the gastrointestinal origin, which is the first cause of ovarian metastasis 7,8, Rare primary ovarian tumors were represented by: adult granulosa cell tumor Figure 2clear cell carcinoma, mixed serous-mucinous carcinoma, and aggressive cancer of the uterus pleomorphic sarcoma 1.

aggressive cancer tumors

Figure 2. Intraoperative Amacroscopic B and microscopic C aspect of a voluminous left aggressive cancer tumors cyst in a patient of 60 years old; after the histopathological analysis the diagnose was adult granulosa cell tumor - note the micro-follicular pattern The earliest age of a patient with ovarian tumor was 31 years old for the mixed serous-mucinous carcinoma, a younger age than mean age for this type of tumor, but cases of patients within 16 to 79 aggressive cancer tumors had been previously reported 13, Mean age distribution was: 52 years old for benign tumors, with a range of 45 to 67 years old; 51 aggressive cancer of the uterus old for borderline tumors, with a range of 32 to 73 years old; 60 years old for malignant tumors, with a range of 31 to 83 years old Figure 3.

Mean age distribution in the category of aggressive cancer tumors tumors is shown in Figure 4. We found a higher age range for benign tumors, but considering the fact that they were associated with borderline tumors, we found it acceptable 2,4.

Figure 3. Age range distribution according to the type of tumor Figure 4.

Aggressive cancer growth

Mean age distribution among malignant ovarian aggressive cancer tumors We had two cases of aggressive cancer tumors recurrence with multiple metastases of previous high-grade serous carcinoma in patients of 62 and paraziti u crijevima simptomi years old, respectively, and one deceased patient of 75 years old, with undifferentiated pleomorphic sarcoma.

They are highly aggressive tumors with poor prognosis, and can develop in younger patients as well. Kurtoglu et al. The most encountered manifestations were: moderate to severe abdominal pain, distention, ascites and anorexia for malignant tumors and mild abdominal distension and menstrual disorders for borderline together with benign tumors.

The symptoms are usually found in large tumors 16, The treatment of ovarian cancer with molecular targeting therapy, platinum and taxane containing chemotherapy and other specific drugs has improved the prognosis over time Currently, the standard primary therapy for advanced disease involves a combination of maximal cytoreductive surgery and chemotherapy with carboplatin plus paclitaxel or with carboplatin alone.

Despite initial high response rates, a large proportion of patients relapse, resulting in a therapeutic challenge 19, Because these patients are not curable, the goal of therapy becomes the improvement in both quality and length of life.

Single-agent aggressive cancer tumors, aggressive cancer of the uterus, aggressive cancer of the uterus pegylated liposomal doxorubicin have demonstrated activity in this patient population and are reasonable treatment options 19, Conclusions In our study, primary malignant tumors are the most frequent type of ovarian tumors and their age incidence ranges from the third to aggressive aggressive cancer tumors of the uterus eighth decade.

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We found higher aggressive cancer of the uterus rates for high-grade serous carcinomas. Studiu clinico-patologic al tumorilor ovariene - experienţa de un an într-un centru medical The majority of secondary ovarian tumors we studied were of endometrial origin, which may suggest that gynecological primary situs can be considered of greater potential of spreading to the ovaries than simptome la paraziti thought.

Bibliografie 1. Histological pattern of aggressive cancer tumors tumors and their age distribution. Nepal Med Coll J. Robbins and Cotran. London, Springer Science Business Aggressive cancer of the uterus, ; Synchronous endometrioid carcinoma of the uterine corpus and ovary.

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A case report and review of the literature. Nucci MR, Oliva E. Gynecologic Pathology. Churchill Livingstone Elsevier; Pathways of metastases from primary organs to the ovaries.

Ovarian cancer development and metastasis. Am J Pathol, ; 3 : — The histologic type and stage distribution of ovarian carcinomas of surface epithelial origin.

A Clinicopathologic study of 35 cases cancer ; Ovarian seromucinous carcinoma: report of a series of a newly categorized and uncommon neoplasm. Am J Surg Pathol, ;39 7 Clinicopathologic study of seromucinous carcinoma of ovary. Undifferentiated pleomorphic sarcoma with focally rhabdomyosarcomatous differentiation of the ovary. Eur J Gynaecol Oncol, aggressive cancer tumors 3 Giant ovarian mucinous cystadenoma with borderline areas: a case report.